| Date | Location | Result | |
| 4/2/22 | Brookings, S.D. (Frost Arena) | South Dakota State 82, Seton Hall 50 | Box score |
| 3/31/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 62, UCLA 59 | Box score |
| 3/27/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 78, Alabama 73 | Box score |
| 3/24/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 84, Drake 66 | Box score |
| 3/20/22 | Brookings, S.D. (Frost Arena) | South Dakota State 78, Minnesota 57 | Box score |
| 3/17/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 87, Ohio 57 | Box score |
| 3/8/22 | Sioux Falls, S.D. (Premier Center) | South Dakota 56, South Dakota St. 45 | Box score |
| 3/7/22 | Sioux Falls, S.D. (Premier Center) | South Dakota St. 72, Oral Roberts 53 | Box score |
| 3/5/22 | Sioux Falls, S.D. (Premier Center) | South Dakota State 86, Denver 59 | Box score |
| 2/26/22 | Brookings, S.D. (Frost Arena) | South Dakota State 94, Kansas City 62 | Box score |
| 2/24/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 84, Oral Roberts 48 | Box score |
| 2/19/222 | St. Paul, Minn. (Schoenecker Arena) | South Dakota St. 83, St. Thomas (MN) 42 | Box score |
| 2/17/22 | Macomb, Ill. (Western Hall) | South Dakota St. 84, Western Ill. 54 | Box score |
| 2/12/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 77, Omaha 62 | Box score |
| 2/10/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 79, Denver 52 | Box score |
| 2/5/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 75, South Dakota 65 | Box score |
| 1/29/22 | Fargo, N.D. (Scheels Center) | South Dakota St. 76, North Dakota St. 60 | Box score |
| 1/27/22 | Grand Forks, N.D. (Betty Engelstad Ctr.) | South Dakota St. 75, North Dakota 49 | Box score |
| 1/22/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 114, Western Ill. 50 | Box score |
| 1/20/22 | Brookings, S.D. (Frost Arena) | South Dakota St. 88, St. Thomas (MN) 47 | Box score |
| 1/15/22 | Denver, Colo. (Hamilton Gymnasium) | South Dakota St. 87, Denver 43 | Box score |
| 1/13/22 | Omaha, Neb. (Baxter Arena) | South Dakota St. 72, Omaha 49 | Box score |
| 1/8/22 | Vermillion, S.D. (Sanford Coyote Center) | South Dakota 65, South Dakota St. 42 | Box score |
| 1/1/2022 | Brookings, S.D. (Frost Arena) | South Dakota St. 72, North Dakota 54 | Box score |
| 12/30/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 77, North Dakota St. 60 | Box score |
| 12/22/21 | Tulsa, Okla. (Mabee Center) | South Dakota St. 71, Oral Roberts 51 | Box score |
| 12/20/21 | Kansas City, Mo. (Swinney Rec Center) | South Dakota St. 85, Kansas City 78 | Box score |
| 12/15/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 90, Dakota Wesleyan 43 | Box score |
| 12/11/21 | Brookings, S.D. (Frost Arena) | Kansas St. 79, South Dakota St. 73 | Box score |
| 12/6/21 | Brookings, S.D. (Frost Arena) | Missouri St. 55, South Dakota St. 52 | Box score |
| 12/4/21 | Cedar Falls, Iowa (MacLeod Center) | UNI 59, South Dakota St. 50 | Box score |
| 11/27/21 | Estero, Fla. | South Dakota St. 76, UCLA 66 | Box score |
| 11/26/21 | Estero, Fla. | Massachusetts 81, South Dakota St. 63 | Box score |
| 11/21/21 | Omaha, Neb. | Creighton 67, South Dakota St. 55 | Box score |
| 11/18/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 78, Montana St. 49 | Box score |
| 11/15/21 | Ames, Iowa (Hilton Coliseum) | Iowa St. 75, South Dakota St. 56 | Box score |
| 11/12/21 | Starkville, Miss. (Humphrey Coliseum) | Mississippi St. 76, South Dakota St. 71 | Box score |
| 11/9/21 | Brookings, S.D. (Frost Arena) | South Dakota St. 70, Green Bay 49 | Box score |